Differential pulse voltammetric determination of paracetamol in tablet and urine samples at a micro-crystalline natural graphite-polystyrene composite film modified electrode

作者：Khaskheli Abdul Rauf; Fischer Jan^*; Barek Jiri; Vyskocil Vlastimil; Sirajuddin; Bhanger Muhammad Iqbal

来源：Electrochimica Acta, 2013, 101: 238-242.

DOI：10.1016/j.electacta.2012.09.102

• Modified electrode
• Graphite-polystyrene composite
• Determination
• Differential pulse voltammetry
• Paracetamol
• Tablet samples
• Human urine samples

A new extremely sensitive method for the determination of paracetamol by differential pulse voltammetry (DPV) using a micro-crystalline natural graphite-polystyrene composite film modified electrode (CFE) was developed. The experimental parameters, such as pH of Britton-Robinson buffer and potentials for regeneration of the electrode surface, were optimized. Under optimized conditions in Britton-Robinson buffer (pH 4.0), linear calibration curves were obtained in the range of 0.02-100 mu mol l(-1) of paracetamol. The limit of determination was 0.034 mu mol l(-1) which shows high sensitivity of the developed method. The method was applied for the determination of paracetamol in pharmaceutical formulations and in human urine model samples.

• 出版日期2013-7-1