Limited generalisability of UPLIFT findings to clinical practice

作者：Walker Steven; Fingleton James; Weatherall Mark; Beasley Richard^*

来源：Thorax, 2013, 68(11): 1066-1067.

DOI：10.1136/thoraxjnl-2013-203724

• COPD Pharmacology

Background The findings of the Understanding Potential Long-term Impacts on Function with Tiotropium (UPLIFT) study may be poorly generalisable to tiotropium use in clinical practice. %26lt;br%26gt;Methods An audit of 226 patients admitted to Wellington Hospital with a chronic obstructive pulmonary disease exacerbation determined the proportion of patients prescribed tiotropium on discharge that would have been ineligible for inclusion in the UPLIFT study. %26lt;br%26gt;Results Among 100 patients prescribed tiotropium, 38/100; 38% (95% CI 28.5% to 48.3%) would have been ineligible for UPLIFT at the time of the hospital discharge due to recent cardiovascular comorbidity or moderate to severe renal impairment. %26lt;br%26gt;Conclusions The UPLIFT findings have limited generalisability to over a third of patients prescribed tiotropium following a hospital admission with a chronic obstructive pulmonary disease exacerbation in New Zealand.

• 出版日期2013-11