A selective fluorescent chemosensor with 1, 2, 4-triazole as subunit for Cu (II) and its application in imaging Cu (II) in living cells

作者：Zhang, Jun^*; Yu, Chunwei; Qian, Shiyun; Lu, Gang; Chen, Jinlong

来源：Dyes and Pigments, 2012, 92(3): 1370-1375.

DOI：10.1016/j.dyepig.2011.09.020

• Rhodamine derivative
• Fluorescent chemosensors
• Triazole
• Metal ions
• Fluorescence enhancement
• Fluorescence imaging

A chemosensor based on rhodamine B with 1, 2, 4-triazole as subunit was synthesized and characterized.. It exhibits high selectivity and sensitivity for Cu2+ in ethanol/water (6:4, v:v) of pH 7.0 HEPES buffer solution and undergoes ring opening mechanism, and a 2:1 metal-ligand complex is formed. The chemosensor displays a linear response to Cu2+ in the range between 1.0 x 10(-7) M and 1.0 x 10(-6) M with a detection limit of 4.5 x 10(-8) M. Its capability of biological application was also evaluated and the results show that this chemosensor could be successfully employed as a Cu2+-selective chemosensor in the fluorescence imaging of living cells.

• 出版日期2012-3
• 单位海南医学院