Arenicolsterol A, a novel cytotoxic enolic sulfated sterol from a marine annelid Arenicola cristata

作者：Chen B; Shen XR; Kong JL^*

来源：Chinese Journal of Chemistry, 2005, 23(5): 599-602.

• marine natural product
• carcinoma
• Arenicola cristata
• sterol

Marine organisms are the important source of the bioactive metabolites. A novel enolic sulfated sterol, arenicolsterol A, has been isolated from a marine annelid Arenicola cristata collected in the coast of Mainland of China. The structure was elucidated using all sorts of spectroscopic data including ESIMS, 1D and 2D NMR etc. The cytotoxic bioactivity of this sterol was evaluated by MTT assay. It could inhibit the growth of human cervix cancer cell line (Hela) and human non-small cell lung cancer cell line (NCI-h6) with IC50 of (3.1 +/- 0.6) mu g/mL and (7.6 +/- 0.8) mu g/mL.

• 出版日期2005-5
• 单位中国人民解放军海军医学研究所; 复旦大学