Guarana, a supplement rich in caffeine and catechin, modulates cytokines: evidence from human in vitro and in vivo protocols

作者：Krewer Cristina da Costa; Suleiman Leila; Medeiros Frescura Duarte Marta Maria; Ribeiro Euler Esteves; Mostardeiro Clarice Pinheiro; Echart Montano Marco Aurelio; de Ugalde Marques da Rocha Maria Izabel; Algarve Thais Doeler; Bresciani Guilherme; Manica da Cruz Ivana Beatrice

来源：European Food Research and Technology, 2014, 239(1): 49-57.

DOI：10.1007/s00217-014-2182-3

• Paullinia cupana
• Guarana
• Cytokines
• Inflammation
• Metabolic disorders

Guarana powder is an antiobesogenic supplement; however, its effect on inflammatory biomarkers has not yet been determined. Therefore, this study analysed whether guarana supplementation can differentially modulate the levels of proinflammatory cytokines [interleukin 6 (IL-6), tumour necrosis factor-alpha, interleukin 1 beta (IL-1 beta), interferon-gamma (Ig-gamma)] and anti-inflammatory interleukin 10 (IL-10) from in vitro and in vivo protocols. In the pilot in vitro protocol, human peripheral blood mononuclear cells were exposed to guarana, as well as to resveratrol, quercetin and ascorbic acid as positive controls. The effect of guarana on cytokine levels was also evaluated in culture medium supplemented with glucose and insulin. A randomised, placebo-controlled in vivo assay was also performed to evaluate the potential influence of guarana on the blood cytokine levels of 14 healthy volunteers supplemented for 14 days. The effect of guarana was similar to that of resveratrol, a known anti-inflammatory molecule, decreasing IL-1 beta, IL-10 and Ig-gamma levels and increasing IL-10 levels compared to those of the control group. The in vitro insulin supplementation potentiated the effect of guarana on some cytokines. A decreasing effect on the blood inflammatory cytokine levels, along with an increase in IL-10 levels, was also observed in volunteers supplemented with guarana. In conclusion, guarana positively modulates cytokines associated with inflammatory metabolism.

• 出版日期2014-7
• 单位IBM