Association between Breast Cancer Risk and the Wild-type Allele of Human ABC Transporter ABCC11

作者：Ota Ikuko; Sakurai Aki; Toyoda Yu; Morita Satoshi; Sasaki Takeshi; Chishima Takashi; Yamakado Minoru; Kawai Yuki; Ishidao Takefumi; Lezhava Alexander; Yoshiura Koh Ichiro; Togo Shinji; Hayashizaki Yoshihide; Ishikawa Takashi; Ishikawa Toshihisa; Endo Itaru; Shimada Hiroshi

来源：Anticancer Research, 2010, 30(12): 5189-5194.

• Apocrine gland
• axillary osmidrosis
• earwax
• mammary gland
• SNP
• ABC transporter ABCC11
• breast cancer risk

Background: International mortality and frequency rates for breast cancer have been associated with the wet type of human earwax. It was recently found that earwax type is determined by a single nucleotide polymorphism (SNP), 538G>A (Gly180Arg), in ABCC11. The G allele determines the wet type of earwax as a Mendelian trait with a dominant phenotype. The present study examined the association between the frequency rate of breast cancer and the frequency of the G allele of ABCC11. Patients and Methods: Using blood samples from patients with invasive breast cancer (n=270) and control volunteers (n=273), the 538G>A SNP in ABCC11 was genotyped using the SmartAmp method. Results: The frequency of the G allele in breast cancer patients was higher than that in healthy controls. The odds ratio for the genotypes (G/G+G/A) to develop breast cancer was estimated to be 1.63 (p-value=0.026), suggesting that the G allele in ABCC11 is associated with breast cancer risk. Conclusion: This study showed that Japanese women with wet earwax have a higher relative risk of developing breast cancer than those with dry earwax. The ABCC11 SNPs that determine these phenotypes should be further investigated in order to obtain insights into the mechanisms by which breast cancer develops and progresses.

• 出版日期2010-12