Differentiating primary CNS lymphoma from glioblastoma multiforme: assessment using arterial spin labeling, diffusion-weighted imaging, and F-18-fluorodeoxyglucose positron emission tomography

作者：Yamashita Koji; Yoshiura Takashi^*; Hiwatashi Akio; Togao Osamu; Yoshimoto Koji; Suzuki Satoshi O; Abe Koichiro; Kikuchi Kazufumi; Maruoka Yasuhiro; Mizoguchi Masahiro; Iwaki Toru; Honda Hiroshi

来源：Neuroradiology, 2013, 55(2): 135-143.

DOI：10.1007/s00234-012-1089-6

• Arterial spin labeling
• Glioblastoma
• Primary CNS lymphoma

Our purpose was to evaluate the diagnostic performance of arterial spin labeling (ASL) perfusion imaging, diffusion-weighted imaging (DWI), and F-18-fluorodeoxyglucose positron emission tomography (FDG-PET) in differentiating primary central nervous system lymphomas (PCNSLs) from glioblastoma multiformes (GBMs). %26lt;br%26gt;Fifty-six patients including 19 with PCNSL and 37 with GBM were retrospectively studied. From the ASL data, an absolute tumor blood flow (aTBF) and a relative tumor blood flow (rTBF) were obtained within the enhancing portion of each tumor. In addition, the minimum apparent diffusion coefficient (ADCmin) and the maximum standard uptake value (SUVmax) were obtained from DWI and FDG-PET data, respectively. Each of the four parameters was compared between PCNSLs and GBMs using Kruskal-Wallis test. The performance in discriminating between PCNSLs and GBMs was evaluated using the receiver-operating characteristics analysis. Area-under-the-curve (AUC) values were compared among the four parameters using a nonparametric method. %26lt;br%26gt;The aTBF, rTBF, and ADCmin were significantly higher in GBMs (mean aTBF +/- SD = 91.6 +/- 56.0 mL/100 g/min, mean rTBF +/- SD = 2.61 +/- 1.61, mean ADCmin +/- SD = 0.78 +/- 0.19 x 10(-3) mm(2)/s) than in PCNSLs (mean aTBF +/- SD = 37.3 +/- 10.5 mL/100 g/min, mean rTBF +/- SD = 1.24 +/- 0.37, mean ADCmin +/- SD = 0.61 +/- 0.13 x 10(-3) mm(2)/s) (p %26lt; 0.005, respectively). In addition, SUVmax was significantly lower in GBMs (mean +/- SD = 13.1 +/- 6.34) than in PCNSLs (mean +/- SD = 22.5 +/- 7.83) (p %26lt; 0.005). The AUC for aTBF (0.888) was higher than those for rTBF (0.810), ADCmin (0.768), and SUVmax (0.848), although their difference was not statistically significant. %26lt;br%26gt;ASL perfusion imaging is useful for differentiating PCNSLs from GBMs as well as DWI and FDG-PET.

• 出版日期2013-2