科研之友
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摘要
Background: High blood levels of asymmetric dimethylarginine (ADMA) are associated with future development of adverse cardiovascular events. The ADMA/symmetric dimethylarginine (SDMA) ratio is a marker of ADMA catabolism, with a high ADMA/SDMA ratio being suggestive of reduced ADMA excretion. %26lt;br%26gt;Aims: This study aimed a) to verify the presence of a statistically significant difference between ADMA/SDMA ratio levels in a group of young adult subjects who were born preterm with an extremely low birth weight (ex-ELBW) and a group of healthy adults born at term and b) to seek correlations between ADMA/SDMA ratio levels in ex-ELBW and anthropometric and clinical parameters (gender, chronological age, gestational age, birth weight, and length of stay in the Neonatal Intensive Care Unit). %26lt;br%26gt;Subjects, study design, outcome measures: Thirty-seven ex-ELBW subjects (11 males [M] and 26 females [F], aged 17-28 years, mean age: 22.2 +/- 1.8 years) were compared with 37 controls (11 M and 26 F). ADMA/SDMA ratio levels were assessed for each patient included in the study. %26lt;br%26gt;Results: ADMA/SDMA ratio in ex-ELBW subjects was higher compared to controls (1.42 +/- 031 vs 0.95 +/- 0.14, p %26lt; 0.002) and inversely correlated with birth weight r = -0.68, p %26lt; 0.0001) and gestational age (r = -0.54, p %26lt; 0.0005). %26lt;br%26gt;Conclusions: ADMA catabolism is significantly decreased in ex-ELBW subjects compared to controls, underlining a probable correlation with restriction of intrauterine growth. These results suggest the onset of early circulatory dysfunction predictive of increased cardiovascular risk in ex-ELBW.
- 出版日期2014-4
