APOE polymorphisms in connection with the susceptibility to osteoporotic fracture

作者：Sun, Jinlei; Dong, Lele; Zhou, Dongsheng^*; Zhao, Yanjun

来源：International Journal of Clinical and Experimental Pathology, 2016, 9(3): 3967-3971.

• Apolipoprotein E
• polymorphism
• polymerase chain reaction
• osteoporotic fracture

Objective: This study was designed to discuss the correlation of apolipoprotein E (APOE) polymorphisms with the susceptibility to osteoporotic fracture. Methods: The bone mineral density (BMD) of 50 osteoporotic fracture patients and 51 healthy people were detected. The APOE genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: The BMD values of different body parts of the patients were apparently lower than those of the healthy people (P< 0.05). The E4 allele of the APOE gene was more frequent in cases than in controls (OR= 3.357, 95% CI= 1.25-8.99). E4 allele carriers had significantly lower BMDs at the Ward's triangle and lumbar L2-L4 segment (P< 0.05). Conclusions: APOE may be correlated with osteoporotic fracture. The E4 allele of the APOE gene may cause a higher likelihood of fracture at Ward's triangle and lumbar L2-L4 segment, and may be a significant marker for osteoporotic fracture.

• 出版日期2016
• 单位内蒙古科技大学包头医学院; 山东大学; 内蒙古科技大学