ASSOCIATION OF IFN-gamma AND P2X7 RECEPTOR GENE POLYMORPHISMS IN SUSCEPTIBILITY TO TUBERCULOSIS AMONG IRANIAN PATIENTS

作者：Shamsi Mahdi; Zolfaghari Mohammad Reza^*; Farnia Parissa

来源：Acta Microbiologica et Immunologica Hungarica, 2016, 63(1): 93-101.

DOI：10.1556/030.63.2016.1.7

• tuberculosis
• IFN-gamma
• IFN-gamma R1
• P2X7
• polymorphisms
• Iran

Interferon-gamma (IFN-gamma) and P2X7 receptor are crucial for host defence against mycobacterial infections. Recent studies have indicated that IFN-gamma, IFN-gamma receptor 1 (IFN-gamma R1) andP2X7 gene polymorphisms are associated with susceptibility to pulmonary tuberculosis (TB). However, the relationship between IFN-gamma and P2X7 polymorphism and TB susceptibility remains inconclusive in Iranian population. For this reason, single nucleotide polymorphisms (SNPs) in IFN-gamma (G+2109A), IFN-gamma R1 (G-611A) and P2X7 genes (at -762, 1513 position) in patients (n = 100) were assessed using PCR-RFLP. Data were analysed with SPSS version 18. For the 2109 loci of IFN-gamma gene, the frequency of mutant alleles between patients and controls were not statistically significant. However, there was a significant difference between the TB patient and controls for -611 alleles of IFN-gamma R1 (P = 0.01). Additionally, the frequency of P2X7 gene polymorphisms (SNP-762 and 1513) between patients and controls was statistically significant. In conclusions, our study revealed a signifi cant association of IFN-gamma R1 and P2X7 genes polymorphisms with risk of developing TB in Iranian population.

• 出版日期2016-3