BPH/LUTS and ED: Common Pharmacological Pathways for a Common Treatment

作者：Fusco Ferdinando^*; D' Anzeo Gianluca; Sessa Aurelio; Pace Gianna; Rossi Andrea; Capece Marco; Bianca Roberta d' Emmanuele di Villa

来源：The Journal of Sexual Medicine, 2013, 10(10): 2382-2393.

DOI：10.1111/jsm.12261

• BPH
• LUTS
• ED
• Treatments
• Phosphodiesterase Type 5 Treatments

Introduction and Aim This article reviews the current literature on common physiopathogenetic factors and pharmacological pathways of lower urinary tract symptoms (LUTS) and erectile dysED) in men and their implications for diagnosis and treatment. %26lt;br%26gt;Main Outcome Measures and MethodsA literature search was conducted to identify original articles, reviews, editorials, and international scientific congress abstracts by combining the following terms: lower urinary tract symptoms, erectile dysfunction and phosphodiesterase type 5 inhibitors (and their abbreviations LUTS, ED and PDE5-Is). %26lt;br%26gt;ResultsWe identified manuscripts presenting: (i) The existence of several newly discovered common pathophysiological mechanisms of LUTS and ED indicating that PDE5-Is might represent an alternative to current treatments of men with LUTS (e.g., 1-adrenergic blockers and 5-reductase inhibitors); (ii) Randomized controlled clinical trials have shown that treatment with PDE5-Is is associated with improvements in both LUTS and ED in men with significant problems in both areas. %26lt;br%26gt;ConclusionThe presence of common pathophysiological mechanisms between LUTS and ED seems well recognized and needs further exploration. Further comparisons between different PDE5-Is would be useful to determine the most appropriate regimen and their efficacy to safety ratio. Fusco F, D%26apos;Anzeo G, Sessa A, Pace G, Rossi A, Capece M, and d%26apos;Emmanuele di Villa Bianca R. BPH/LUTS and ED: Common pharmacological pathways for a common treatment. J Sex Med 2013;10:2382-2393.

• 出版日期2013-10