Activation of canonical WNT/beta-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition

作者：Kahlert Ulf D; Maciaczyk Donata; Doostkam Soroush; Orr Brent A; Simons Brian; Bogiel Tomasz; Reithmeier Thomas; Prinz Marco; Schubert Joerg; Niedermann Gabriele; Brabletz Thomas; Eberhart Charles G; Nikkhah Guido; Maciaczyk Jaroslaw^*

来源：Cancer Letters, 2012, 325(1): 42-53.

DOI：10.1016/j.canlet.2012.05.024

• Glioblastoma
• beta-Catenin
• ZEB1
• Epithelial-to-mesenchymal transition (EMT)
• Invasion

Here we show that activation of the canonical WNT/beta-catenin pathway increases the expression of stem cell genes and promotes the migratory and invasive capacity of glioblastoma. Modulation of WNT signaling alters the expression of epithelial-to-mesenchymal transition activators, suggesting a role of this process in the regulation of glioma motility. %26lt;br%26gt;Using immunohistochemistry in patient-derived glioblastoma samples we showed higher numbers of cells with intranuclear signal for beta-catenin in the infiltrating edge of tumor compared to central tumor parenchyma. These findings suggest that canonical WNT/beta-catenin pathway is a critical regulator of GBM invasion and may represent a potential therapeutic target.

• 出版日期2012-12-1