Direct and Transdentinal (Indirect) Antibacterial Activity of Commercially Available Dental Gel Formulations against Streptococcus mutans

作者：Tuzuner Tamer^*; Ulusoy Ayca Tuba; Baygin Ozgul; Yahyaoglu Gorkem; Yalcin Ilkay; Buruk Kurtulus; Nicholson John

来源：Medical Principles and Practice, 2013, 22(4): 397-401.

DOI：10.1159/000347234

• Antibacterial dental gels
• Streptococcus mutans
• Cavity disinfectant
• Chlorhexidine
• Aloe vera
• Hyaluronic acid

Objective: To evaluate the direct and transdentinal (indirect) agar diffusion antibacterial activity of different commercially available antibacterial dental gel formulations against Streptococcus mutans. Materials and Methods: The commercially available dental gel formulations were Corsodyl (R) (COG, 1% chlorhexidine), Cervitec (R) (CEG, 0.2% chlorhexidine + 0.2% sodium fluoride), Forever Bright (R) (FOB, aloe vera), Gengigel (R) (GEG, 0.2% hyaluronic acid), 35% phosphoric acid gel and distilled water (control). Direct agar diffusion was performed by isolating three wells from brain-heart infusion agar plates using sterile glass pipettes attached to a vacuum pump and adding 0.1 ml of the gels to each well. Transdentinal (indirect) agar diffusion was performed by applying gel to 0.2- and 0.5-mm-thick human dentin discs previously etched with phosphoric acid and rinsed with distilled water. Zones formed around the wells and the dentin discs were measured and analyzed using Kruskal-Wallis and Mann-Whitney U tests with Bonferroni correction (p < 0.01). Results: Direct agar diffusion tests showed significant differences among all gel formulations (p < 0.01) except for COG and CEG (p > 0.01). COG and CEG exhibited higher antibacterial effects compared to FOB and GEG (p < 0.01) in both direct and transdentinal (indirect) testing procedures. GEG did not show any antimicrobial activity in transdentinal (indirect) testing. Conclusion: Commercially available dental gels inhibited S. mutans, which may indicate their potential as cavity disinfectants.

• 出版日期2013