Antimicrobial Effects of Chemical Compounds Isolated Traditional Chinese Herbal Medicine (TCHM) Against Drug-Resistant Bacteria: A Review Paper

作者：Zhao, Yanling^*; Li, Haotian; Wei, Shizhang; Zhou, Xuelin; Xiao, Xiaohe

来源：Mini Reviews in Medicinal Chemistry, 2019, 19(2): 125-137.

DOI：10.2174/1389557518666181017143141

• Traditional Chinese Herbal Medicine (TCHM)
• drug-resistant bacteria
• TCHM-derived compounds
• antibacterial effect
• shigellosis
• tuberculosis

Infectious diseases caused by pathogenic bacteria seriously threaten human lives. Although antibiotic therapy is effective in the treatment of bacterial infections, the overuse of antibiotics has led to an increased risk of antibiotic resistance, putting forward urgent requirements for novel antibacterial drugs. Traditional Chinese herbal medicine (TCHM) and its constituents are considered to be potential sources of new antimicrobial agents. Currently, a series of chemical compounds purified from TCHM have been reported to fight against infections by drug-resistant bacteria. In this review, we summarized the recent findings on TCHM-derived compounds treating drug-resistant bacterial infections. Further studies are still needed for the discovery of potential antibacterial components from TCHM.

• 出版日期2019
• 单位中国人民解放军第三０二医院