Association of circulating cytochrome c with clinical manifestations of antiretroviral-induced toxicity

作者：Langs Barlow Allison; Selvaraj Shanmugapriya; Ogbuagu Onyema; Shabanova Veronika; Shapiro Eugene D; Paintsil Elijah^*

来源：Mitochondrion, 2015, 20: 71-74.

DOI：10.1016/j.mito.2014.11.004

• Antiretroviral therapy
• Cytochrome c
• Mitochondrial toxicity

Diagnosis of antiretroviral therapy (ART) toxicity is complicated. Apoptosis has been implicated in ART toxicity. Cytochrome c (Cyt-C) is a mitochondrial protein found in plasma during pro-apoptotic states. We conducted a study of HIV-infected individuals on ART with (cases, n = 21) and without (controls, n = 21) clinical evidence of toxicity to determine if elevated plasma Cyt-C is associated with ART toxicity. When corrected for CD4 count, viral load, and duration of HIV infection, cases are 7.86 times more likely than controls to have plasma Cyt-C > 0.216 ng/mL Cyt-C could be a useful clinical tool to guide treatment decisions in this population.

• 出版日期2015-1