Multicenter Prospective Randomized Phase II Study of Antimicrobial Prophylaxis in Low-Risk Patients Undergoing Colon Surgery

作者：Shimizu Junzo^*; Ikeda Kimimasa; Fukunaga Mutsumi; Murata Kohei; Miyamoto Atsushi; Umeshita Koji; Kobayashi Tetsuro; Monden Morito

来源：Surgery Today, 2010, 40(10): 954-957.

DOI：10.1007/s00595-009-4176-5

• Antimicrobial prophylaxis
• Surgical site infection

Purpose. Postoperative antimicrobial therapy is generally administered as standard prophylaxis against postoperative infection, despite a lack of sufficient evidence for its usefulness. This study was a phase II study to evaluate the necessity of postoperative antibiotic prophylaxis in patients undergoing a colectomy.
Methods. Patients received 1 g cefmetazole or flomoxef immediately after anesthetic induction, every 3 h during surgery, and then later once again on the next day. They were randomly assigned to receive either cefmetazole or flomoxef.
Results. Ninety-one patients were enrolled in the study. A surgical site infection (SSI) occurred in 7.7% (7/91) of patients. All cases were superficial incisional infections. When comparing the two drugs, SSI occurred in 8.3% (4/48) of patients treated with cefmetazole and in 7.0% (3/43) treated with flomoxef, showing no significant difference (P > 0.99).
Conclusion. Antimicrobial prophylaxis was well tolerated when used on the day of a colectomy and once again on the next day.

• 出版日期2010-10