Are drowned donors marginal donors? A single pediatric center experience

作者：Kumm Kayla R; Galvan N Thao N; Koohmaraie Sarah; Rana Abbas; Kueht Michael; Baugh Katherine; Hao Liu; Yoeli Dor; Cotton Ronald; O'Mahony Christine A; Goss John A^*

来源：Pediatric Transplantation, 2017, 21(6): e13009.

DOI：10.1111/petr.13009

• drowned donor
• drowning
• marginal donor
• orthotopic liver transplantation
• pediatric liver transplantation

Drowning, a common cause of death in the pediatric population, is a potentially large donor pool for OLT. Anecdotally, transplant centers have deemed these organs high risk over concerns for infection and graft dysfunction. We theorized drowned donor liver allografts do not portend worse outcomes and therefore should not be excluded from the donation pool. We reviewed our single-center experience of pediatric OLTs between 1988 and 2015 and identified 33 drowned donor recipients. These OLTs were matched 1:2 to head trauma donor OLTs from our center. A chart review assessed postoperative peak AST and ALT, incidence of HAT, graft and recipient survival. Recipient survival at one year between patients with drowned donor vs head trauma donor allografts was not statistically significant (94% vs 97%, P=.63). HAT incidence was 6.1% in the drowned donor group vs 7.6% in the control group (P=.78). Mean postoperative peak AST and ALT was 683 U/L and 450 U/L for drowned donors vs 1119 U/L and 828 U/L in the matched cohort. These results suggest drowned donor liver allografts do not portend worse outcomes in comparison with those procured from head trauma donors.

• 出版日期2017-9