A Child With Severe Hearing Loss Associated With Maternal Cisplatin Treatment During Pregnancy

作者：Geijteman Eric C T^*; Wensveen Celesta W M; Duvekot Johannes J; van Zuylen Lia

来源：Obstetrics and Gynecology, 2014, 124(2): 454-456.

DOI：10.1097/AOG.0000000000000389

BACKGROUND: Cisplatin is considered safe to use during the second and third trimesters of pregnancy in patients with cancer.
CASE: A 34-year-old pregnant woman was diagnosed with cervical cancer. She received five weekly dosages of cisplatin and paclitaxel, starting at 26 5/7 weeks of gestation. An elective cesarean delivery was performed at 34 4/7 weeks of gestation. After birth, the neonate was diagnosed with severe bilateral perceptive hearing loss.
CONCLUSION: Cisplatin during the second and third trimesters of pregnancy may lead to fetal ototoxicity.

• 出版日期2014-8