Antidiabetic Effects of Vigna nakashimae Extract in db/db Mice

作者：Yeo Ji Young; Ha Tae Joung; Nam Jeong Su; Jung Myeong Ho^*

来源：Bioscience Biotechnology and Biochemistry, 2011, 75(11): 2223-2228.

DOI：10.1271/bbb.110538

• type 2 diabetes
• Vigna nakashimae
• postprandial hyperglycemia
• alpha-glucosidase inhibitory activity
• endoplasmic reticulum stress

The inhibitory activity of Vigna nakashimae extract against intestinal a-glucosidase was investigated in vitro and in vivo. The extract exerted a significant inhibitory effect against intestinal alpha-glucosidases. With sucrose-loading, it reduced the peak responses of blood glucose significantly in normal mice. Next, it was administrated to 8-week-old db/db mice for 2 weeks, and then plasma glucose, triglyceride, and total cholesterol levels were measured. The extract significantly suppressed postprandial hyperglycemia and blood glycated hemoglobin in the db/db mice. In addition, it lowered fasting glucose and improved glucose tolerance. Furthermore, it led to significant decreases in plasma triglyceride levels. It reduced endoplasmic reticulum stress in thapsigargin-induced HepG2 cells. Taken together, these results suggest that Vigna nakashimae extract has hypoglycemic and hypolipidemic effects that occur via inhibition of a-glucosidase activity and endoplasmic reticulum stress.

• 出版日期2011-11