科研之友
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摘要
To study the effect of feeding pharmacological level of bovine lactoferricin (LFcin), 20 weaned piglets (5.29 +/- 0.19 kg) were randomly assigned to four treatment groups and fed a maize-soyabean meal diet containing either no addition (C), 100 mg/kg of cipB (C + B), 100 mg/kg of cipB-LFcin (C + L) or 100 mg/kg of colistin sulphate (C + CS) for 3 weeks. Compared with C and C + B, dietary LFcin reduced faecal score (P < 0.05), decreased the concentration of Escherichia coli in the duodenum, jejunum and ileum (P < 0.05), increased the concentration of lactobacillus and bifidobacterium in the duodenum, jejunum and ileum (P < 0.05), and promoted development of the villus-crypt architecture of the jejunum and ileum. Dietary supplementation with LFcin decreased serum levels of cytokines (interleukin-1,6 [IL-1,6], tumour necrosis factor-alpha [TNF-alpha]) (P < 0.05) and glucagon (P < 0.05), and increased growth hormone (P < 0.05). Thus LFcin could relieve the weanling stress in 21-day weaned piglets.
