SNAP-25 genotype influences NAA/Cho in left hippocampus

作者：Scherk Harald^*; Backens Martin; Zill Peter; Schneider Axmann Thomas; Wobrock Thomas; Usher Juliana; Reith Wolfgang; Falkai Peter; Moeller Hans Juergen; Bondy Brigitta; Gruber Oliver

来源：Journal of Neural Transmission, 2008, 115(11): 1513-1518.

DOI：10.1007/s00702-008-0103-y

• Proton magnetic resonance spectroscopy
• SNAP-25
• N-acetyl-aspartate
• Choline
• Hippocampus

The SNAP-25 gene is an integral part of the vesicle docking and fusion machinery that controls neurotransmitter release. Several post mortem studies revealed a reduction of SNAP-25 protein in the hippocampus of patients with schizophrenia and bipolar disorder (BD). Thirty-eight patients with schizophrenia, BD or obsessive-compulsive disorder and 17 healthy controls participated in the study. Proton magnetic resonance spectroscopy in left hippocampus was performed in each individual. Three single nucleotide polymorphisms (SNP) of the SNAP-25 gene were genotyped. Individuals with the homozygous CC genotype of the DdeI SNP presented a significantly higher ratio of N-acetyl-aspartate (NAA)/choline-containing compounds (Cho) in the left hippocampus compared to the group of individuals with the homozygous TT genotype. The SNAP-25 genotype may modulate synaptic plasticity and neurogenesis in the left hippocampus, and altered NAA/Cho ratio may be an indicator for this genetic modulation of neuronal function in the hippocampus.

• 出版日期2008-11