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摘要
Aims. The impact of ApoE polymorphism on angiographic parameters was assessed in patients referred for coronary angiography. %26lt;br%26gt;Methods. Elective coronary angiography was performed in 671 subjects (525 men, 146 women, mean age 60 +/- 10 years) with symptoms of ischemic heart disease. The patients were divided into: no CAD group (smooth coronary vessels, n=83), one-vessel (n=155), two-vessel (n=170) and three-vessel disease (n=196). Patients with stenoses 0-50% were excluded. Within patients with CAD, we evaluated overall extent of CAD measured by the number of stenotic segments according to AHA (1 segment vs. 2-3 vs. %26gt;= 4), and the severity of the most serious stenosis (in percent). ApoE genotype was determined using real-time PCR. %26lt;br%26gt;Results. The frequency of epsilon 2/epsilon 3 genotype (n=56) was lower in the three-vessel disease group compared to one-vessel disease (OR=0.25, P=0.0019), two-vessel disease (OR=0.31, P=0.0114) or no CAD group (OR=0.24, P=0.0057). Frequency of epsilon 2/epsilon 3 decreased with the number of affected segments (1 vs. %26gt;= 4: OR=0.35, P=0.0143). The epsilon 3/epsilon 4+epsilon 4/epsilon 4 genotypes (n=123) were more frequent in CAD patients altogether compared with no CAD group (OR=2.30, P=0.019), while no impact of the epsilon 4 allele on angiographic parameters within the CAD patients was detected. In epsilon 2/epsilon 3 carriers with CAD, lower LDL-cholesterol, total cholesterol and lower use of lipid-lowering drugs were observed. %26lt;br%26gt;Conclusions. The results show predominantly focal form of CAD in patients with epsilon 2/epsilon 3 genotype. Lower LDL-cholesterol and total cholesterol may play the key role, although other contributing factors are discussed.
- 出版日期2012
