Flavonoids as matrices for MALDI-TOF mass spectrometric analysis of transition metal complexes

作者：Petkovic Marijana^*; Petrovic Biljana; Savic Jasmina; Bugarcic Zivadin D; Dimitric Markovic Jasmina; Momic Tatjana; Vasic Vesna

来源：International Journal of Mass Spectrometry, 2010, 290(1): 39-46.

DOI：10.1016/j.ijms.2009.12.001

• Ru(III) complex
• Pt-complex
• Pd complex
• MALDI-TOF MS
• Flavonoid

Matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a suitable method for the analysis of inorganic and organic compounds and biomolecules This makes. MALDI-TOF MS convenient for monitoring the interaction of metallo-drugs with biomolecules. Results presented in this manuscript demonstrate that flavonoids such as apigenin, kaempferol and luteolin are suitable for MALDI-TOF MS analysis of Pt(II), Pd(II), Pt(IV) and Ru(III) complexes, giving different signal-to-noise ratios of the analyte peak. The MALDI-TOF mass spectra of inorganic complexes acquired with these flavonoid matrices are easy to interpret and have some advantages over the application of other commonly used matrices: a low number of matrix peaks are detectable and the coordinative metal-ligand bond is, in most cases, preserved. On the other hand, flavonoids do not act as typical matrices, as their excess is not required for the acquisition of MALDI-TOF mass spectra of inorganic complexes.

• 出版日期2010-2-1