Association of K-ras codon 12 transversions with short survival in non-small cell lung cancer

作者：Vega FJ; Iniesta P; Caldes T; Sanchez A; Lopez JA; DeJuan C; DiazRubio E; Torres A; Balibrea JL; Benito M

来源：International Journal of Oncology, 1996, 9(6): 1307-1311.

• K-ras
• transversion
• survival
• NSCLC

K-ras activating point mutations appear to have a role in human lung cancer, however, the prognostic significance of these abnormalities remains unclear. The aim of our work was to clarify the role of K-ras mutations as prognostic indicators in patients affected by non-small cell lung cancer (NSCLC). We studied 94 resected primary NSCLCs for K-ras mutations by the PCR-RFLP technique, followed by sequencing. K-ras activating mutations were present in 34% of tumors, a higher incidence being detected in adenocarcinomas. Comparing the impact of K-ras mutation types, we found that K-ras transversions were associated with a shorter survival in NSCLC.

• 出版日期1996-12