A METHOD FOR THE PREDICTION OF LATE ORGAN-AT-RISK TOXICITY AFTER RADIOTHERAPY OF THE PROSTATE USING EQUIVALENT UNIFORM DOSE

作者：Fleming Cathy^*; Kelly Colin; Thirion Pierre; Fitzpatrick Kathryn; Armstrong John

来源：International Journal of Radiation Oncology, Biology, Physics, 2011, 80(2): 608-613.

DOI：10.1016/j.ijrobp.2010.07.1994

• Late rectal toxicity
• Late bladder toxicity
• Prostate
• Equivalent uniform dose (EUD)
• 3D-CRT

Purpose: To evaluate the predictive value of equivalent uniform doses (EUD) for late bladder and rectal toxicity after high-dose three-dimensional conformal radiation therapy (3D-CRT) to the prostate.
Materials and Methods: Using the method developed by Kutcher et al., EUDs for whole bladder and rectum were calculated from the dose volume histograms of 180 patients with localized prostate cancer treated to 70-74 Gy with 3D-CRT. Late complications were recorded using the Radiation Therapy Oncology Group scale, correlated against EUD and known physical predictive indicators.
Results: EUD is an independent prognostic factor for Grade 2+ long-term rectal and bladder toxicity after radiation treatment to the prostate. Patients receiving an EUD >63.1 Gy to the rectum have a statistically significant (10% vs. 30%; p = 0.002) higher risk of developing Grade 2+ late complications. Patients receiving an EUD >53.4 Gy to the bladder have a statistically significant (10% vs. 33%;p = 0.001) higher risk of developing Grade 2+ late complications.
Conclusions: It has been demonstrated that EUD is a strong independent predictive factor for Grade 2+ late complications after 3D-CRT to the prostate. Threshold values have been demonstrated for both bladder and rectum, above which there is a clinically significant increased risk of complications.

• 出版日期2011-6-1