Amyloid and its association with default network integrity in Alzheimer's disease

作者：Adriaanse Sofie M^*; Sanz Arigita Ernesto J; Binnewijzend Maja A A; Ossenkoppele Rik; Tolboom Nelleke; van Assema Danielle M E; Wink Alle Meije; Boellaard Ronald; Yaqub Maqsood; Windhorst Albert D; van der Flier Wiesje M; Scheltens Philip; Lammertsma Adriaan A; Rombouts Serge A R B; Barkhof Frederik; van Berckel Bart N M

来源：Human Brain Mapping, 2014, 35(3): 779-791.

DOI：10.1002/hbm.22213

• magnetic resonance imaging
• positron emission tomography
• default mode network
• Alzheimer disease
• resting-state fMRI
• mild cognitive impairment
• amyloid

The purpose of this study was to investigate the association between functional connectivity and beta-amyloid depositions in the default mode network (DMN) in Alzheimer's disease (AD), patients with mild cognitive impairment (MCI), and healthy elderly. Twenty-five patients with AD, 12 patients with MCI, and 18 healthy controls were included in the study. Resting-state functional magnetic resonance imaging was used to assess functional connectivity in the DMN. In parallel, amyloid burden was measured in the same subjects using positron emission tomography with carbon-11-labeled Pittsburgh Compound-B as amyloid tracer. Functional connectivity of the DMN and amyloid deposition within the DMN were not associated across all subjects or within diagnostic groups. Longitudinal studies are needed to examine if amyloid depositions precede aberrant functional connectivity in the DMN. Hum Brain Mapp 35:779-791, 2014.

• 出版日期2014-3