Asymmetric Direct Aldol Reaction of Cyclohexanone Catalyzed by (N '-Benzyl-N '-D-prolyl)-trans-4-hydroxy-L-proline Hydrazide

作者：Cheng Chuanling^*; Wang Wenliang

来源：Chinese Journal of Chemistry, 2011, 29(1): 196-198.

DOI：10.1002/cjoc.201190051

• asymmetric aldol reaction
• proline hydrazide
• enantioselectivity
• diastereoselectivity
• cyclohexanone

A new proline catalyst, namely (N'-benzyl-N'-D-prolyl)-trans-4-hydroxy-L-proline hydrazide, has been prepared and proved to be a superior catalyst for the asymmetric aldol reaction of cyclohexanone and aromatic aldehydes, affording up to 98 : 2 dr and 98% ee.

• 出版日期2011-1
• 单位郑州轻工业大学