An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne

作者:Spiteri Christian; Mason Christopher; Zhang Fengzhi; Ritson Dougal J; Sharma Pallavi; Keeling Steve; Moses John E*
来源:Organic and Biomolecular Chemistry, 2010, 8(11): 2537-2542.
DOI:10.1039/b927235f

摘要

An efficient protocol for the synthesis of a range of 1,2-benzisoxazoles using an improved 1,3-dipolar cycloaddition of nitrile oxides and benzyne is described. Key to the procedure is the in situ generation of the reactive nitrile oxide and benzyne reactants simultaneously.

  • 出版日期2010