Systematic Review of Association Between Low Ankle-Brachial Index and All-Cause Cardiovascular, or Non-cardiovascular Mortality

作者：Qu, Baoze; Liu, Qifeng; Li, Jinzhao^*

来源：Cell Biochemistry and Biophysics, 2015, 73(2): 571-575.

DOI：10.1007/s12013-015-0582-z

• Ankle-brachial index
• All-cause mortality
• Cardiovascular death
• Non-cardiovascular death

The ankle-brachial index (ABI) is the ratio of the ankle versus brachial systolic blood pressure. ABI of < 0.90 indicates the presence of peripheral arterial disease. Some studies indicated that ABI may correlate with the all-cause mortality. The aim of this study was to assess the prognostic significance of ABI of < 0.90 as such predictor of all-cause mortality. In addition, we wished to test the association between ABI and cardiovascular or non-cardiovascular mortality. To this end, we carried out a systematic review of the studies published in MEDLINE that reported both ABI and all-cause mortality. The endpoint of interest was the all-cause mortality, including death from coronary disease, stroke, or other causes. Ten studies, with a total of 22,705 patients, were included in this review. ABI of < 0.90 was proved to be associated with an increased risk of all-cause mortality [odds ratio 2.74 (95 % confidence interval 2.03-3.68) and number needed to harm 1.66], as well as with cardiovascular [i.e., death from coronary disease or stroke; respectively, 3.23 (1.98-5.29) and 1.26] and non-cardiovascular mortality [respectively, 2.23 (1.40-3.55) and 1.29]. In conclusion, ABI of < 0.9 is useful as a prognostic factor for all-cause mortality.

• 出版日期2015-11
• 单位锦州医科大学