New isoprenylated flavones, artochamins A-E, and cytotoxic principles from Artocarpus chama

作者：Wang YH; Hou AJ^*; Chen L; Chen DF; Sun HD; Zhao QS; Bastow KF; Nakanish Y; Wang XH; Lee KH

来源：Journal of Natural Products, 2004, 67(5): 757-761.

DOI：10.1021/np030467y

Five new isoprenylated flavones, artochamins A-E (1-5), together with eight known flavones (6-13), were isolated from the roots of Artocarpus chama. All structures were elucidated by spectroscopic methods. Artonin E (12) showed strong cytotoxicity against 1A9 (ovarian), significant activity against MCF-7 (breast adenocarcinoma), and moderate activity against HCT-8 (ileocecal) and MDA-MB-231 (breast adenocarcinoma) tumor cell lines. Artochamin C (3) was more potent against MCF-7, 1A9, HCT-8, and SK-MEL-2 (melanoma) than A549 (lung carcinoma), KB (epidermoid carcinoma of the nasopharynx), and its drug-resistant (KB-VIN) variant. Artocarpin (6) displayed weak but relatively broad inhibitory effects compared with 3 and 12.

• 出版日期2004-5
• 单位中国科学院昆明植物研究所; 复旦大学