Neuropsychological rehabilitation has beneficial effects on perceived cognitive deficits in multiple sclerosis during nine-month follow-up

作者：Rosti Otajarvi Eija^*; Mantynen Anu; Koivisto Keijo; Huhtala Heini; Hamalainen Paivi

来源：Journal of the Neurological Sciences, 2013, 334(1-2): 154-160.

DOI：10.1016/j.jns.2013.08.017

• Attention
• Follow-up
• Long-term
• Multiple sclerosis
• MS
• Neuropsychological rehabilitation

Background: Systematic reviews have indicated a low level of evidence for the positive effects of neuropsychological and cognitive rehabilitation in multiple sclerosis (MS). How permanent the positive effects are, is unknown. %26lt;br%26gt;Objective: The aim of the present study was to evaluate whether short-term neuropsychological rehabilitation has long-term beneficial effects in a nine-month follow-up. %26lt;br%26gt;Methods: 102 relapsing remitting MS patients with subjective and objective attentional deficits were randomized into intervention and control groups. Altogether 78 out of 102 patients (76%) completed the longitudinal follow-up (intervention group 83%, control group 67%). Intervention group received strategy-oriented neuropsychological rehabilitation conducted once a week in 60-minute sessions during thirteen consecutive weeks. The control group received no intervention. Cognitive deficits, mood, fatigue, impact of disease, and quality of life were evaluated with self-reports at baseline, six months, and one year from baseline. %26lt;br%26gt;Results: The positive effects of neuropsychological rehabilitation on perceived cognitive deficits were maintained for nine months. Among a subgroup of patients with moderate to severe attentional deficits, positive rehabilitation outcome was even more evident. %26lt;br%26gt;Conclusion: The beneficial effects of strategy-oriented neuropsychological rehabilitation on perceived cognitive deficits in MS may be maintained for at least one year after the beginning of the intervention.

• 出版日期2013-11-15