Duloxetine-induced rapid eye movement sleep behavior disorder: a case report

作者：Tan, Lu; Zhou, Junying; Yang, Linghui^*; Ren, Rong; Zhang, Ye; Li, Taomei; Tang, Xiangdong

来源：BMC Psychiatry, 2017, 17(1): 372.

DOI：10.1186/s12888-017-1535-4

• Duloxetine
• Rapid eye movement sleep behavior disorder
• Polysomnography

Background: Tricyclic antidepressants and selective serotonin reuptake inhibitors have been reported to induce the symptoms of rapid eye movement (REM) sleep behavior disorder (RBD) or to exacerbate REM sleep without atonia. With this case report, we found an association between typical RBD and duloxetine, a serotonin-noradrenaline reuptake inhibitor. @@@ Case presentation: We present a case of a 62-year-old woman who experienced enactment behaviors with violent dreams that were associated with increased tonic or phasic chin electromyography activity during REM sleep after treated with duloxetine. RBD symptoms were gradually reduced and completely ceased after discontinuation of duloxetine for 37 days. @@@ Conclusion: The current case appears to be the first observation of duloxetine-induced RBD. We describe features of RBD induced by duloxetine that are similar and different from that induced by tricyclic antidepressants and selective serotonin reuptake inhibitors.

• 出版日期2017-11-21
• 单位四川大学