A new acetophenone derivative from flowers of Helichrysum italicum (Roth) Don ssp italicum

作者：Rigano Daniela; Formisano Carmen; Pagano Ester; Senatore Felice; Piacente Sonia; Masullo Milena; Capasso Raffaele; Izzo Angelo A; Borrelli Francesca^*

来源：Fitoterapia, 2014, 99: 198-203.

DOI：10.1016/j.fitote.2014.09.019

• Acetophenones
• Antioxidant
• Asteraceae
• Helichrysum italicum
• Inflammation
• Reactive oxygen species

A new acetophenone derivative named gnaphaliol 9-O-propanoate (1) was isolated from the chloroform fraction of EtOH extract of Helichrysum italicum ssp. italicum flowers along with the five known acetophenones 12-acetoxytremetone (2), 13-(2-methylpropanoyloxy)toxol (3), [2,3-dihydro-2-[1-(hydroxymethyl)ethenyl]-5-benzofuranyl]-ethanone (4), 1-[2-[1-[(acetyloxy)methyl]ethenyl]-2,3-dihydro-3-hydroxy-5-benzofuranyl]-ethanone (5) and gnaphaliol (6). The structures of compounds 1-6 were elucidated by extensive spectroscopic methods including 1D- (H-1 and C-13) and 2D-NMR (DQF-COSY, HSQC, HMBC, TOCSY and ROESY) experiments as well as ESIMS analysis. The isolated compounds were investigated for their cytotoxicity, anti-inflammatory and antioxidant properties. Biological assays on human colonic epithelial cells showed that compound 2 possessed antioxidant effects reducing reactive oxygen species (ROS) production.

• 出版日期2014-12