Accessing chemical diversity by stereoselective gold-catalyzed manipulation of allylic and propargylic alcohols

作者：Cera Gianpiero; Chiarucci Michel; Bandini Marco^*

来源：Pure and Applied Chemistry, 2012, 84(8): 1673-1684.

DOI：10.1351/PAC-CON-11-09-05

• asymmetric catalysis
• gold
• heterocyclic chemistry

The combined use of asymmetric Au(I) catalysis with allylic as well as propargylic alcohols proved to be a competent synthetic tool, toward the realization of complex molecular organic architectures in a stereochemically defined manner. In particular, allylic alcohols have been utilized as alkylating agents in the synthesis of tetrahydrocarbazoles/carbolines and morpholines by means of new C-C and C-X bond-forming processes. Analogously, the direct activation of indole-propargylic alcohols with cationic Au complexes opened a direct access to tetracyclic fused indolines in a highly stereoselective manner.

• 出版日期2012