Amino acid containing amorphous calcium phosphates and the rapid transformation into apatite

作者：Ikawa Nobuaki; Kimura Tatsuo; Oumi Yasunori; Sano Tsuneji^*

来源：Journal of Materials Chemistry, 2009, 19(28): 4906-4913.

DOI：10.1039/b815154g

Amorphous calcium phosphates can be obtained successfully in the presence Of L-glutamic acid (Glu), L-aspartic acid (Asp), and L-lysine (Lys) with carboxyl and amino groups that are present in biomolecules such as collagen. Composition (Ca/P molar ratio) of the inorganic frameworks was controllable according to the kind of the organic molecules used. Ca- (Ca/P approximate to 1.8) and P-rich (Ca/P approximate to 1.0) products were obtained using dicarboxylic acid- (Glu and Asp) and diamine-type (Lys) amino acids, respectively. The amino acid containing calcium phosphates were transformed into apatite much faster than alpha-tricalcium phosphate (alpha-TCP) when immersed in simulated body fluid (SBF). The addition of the Ca-rich composites to calcium phosphate cement promoted the transformation into apatite. indicating that the amino acid containing amorphous calcium phosphates are highly promising as precursors for bone substitutes.

• 出版日期2009-7-28