A cysteine-type carboxypeptidase, cathepsin X, generates peptide receptor agonists

作者：Nagler Dorit K^*; Kraus Steffen; Feierler Jens; Mentele Reinhard; Lottspeich Friedrich; Jochum Marianne; Faussner Alexander

来源：International Immunopharmacology, 2010, 10(1): 134-139.

DOI：10.1016/j.intimp.2009.09.018

• Angiotensin
• Bradykinin
• Kallidin
• Protease
• Radioreceptor assay

The kallikrein-kinin system and the renin-angiotensin system interact at different levels and are linked by various molecules such as angiotensin-converting enzyme which degrades bradykinin into inactive peptides. Here we report that a cysteine-type carboxypeptidase, cathepsin X, is able to modulate the kallikrein-kinin system through carboxyterminal processing of the small peptide hormones bradykinin and kallidin Both peptides are thereby converted from bradykinin B(2) receptor ligands to bradykinin B(1) receptor specific ligands Cathepsin X, which has previously been recognized as an inflammatory marker may therefore act as a type I kininase In addition, we have identified cathepsin X as an alternative possible link between t

• 出版日期2010-1