Association of plasma adiponectin levels with oxidative stress in Hemodialysis patients

作者：Lim Paik Seong^*; Chen Shun Liang; Wu Ming Ying; Hu Chuen Yuh; Wu Tsai Kun

来源：Blood Purification, 2007, 25(4): 362-369.

DOI：10.1159/000107509

• adipocytes
• adiponectin
• atherosclerosis
• metabolic syndrome
• oxidative stress

Background: Recent evidence suggests that oxidative stress may be an instigator of the metabolic syndrome, and adiponectin, an adipocyte- derived polypeptide, may modulate oxidative stress, ameliorating the atherosclerotic process. Aim: Oxidative stress is increased in hemodialysis ( HD) patients. We hypothesize that a relationship between plasma levels of adiponectin and markers of inflammation and oxidative stress exists. Methods and Results: In 124 HD patients, plasma adiponectin levels and three separate oxidative stress markers, tumor necrosis factor- alpha as well as high- sensitivity C- reactive protein ( hs CRP) were determined. Plasma adiponectin was significantly and negatively correlated with serum hs CRP ( r = - 0.247, p = 0.008) and plasma malondialdehyde ( MDA) levels ( r = - 0.326; p < 0.001). Multiple regression analyses suggested that plasma MDA, serum HDL cholesterol levels and logarithmically transformed hs CRP were the variables independently associated with plasma adiponectin levels. Conclusion: Plasma adiponectin was significantly associated with plasma MDA, serum HDL cholesterol levels and serum hs CRP levels. Our results suggest the possibility that plasma adiponectin may play a role in alleviating oxidative stress in HD patients.

• 出版日期2007