aza-Flavanones as potent cross-species microRNA inhibitors that arrest cell cycle

作者：Chandrasekhar Srivari^*; Pushpavalli Sreerangam N C V L; Chatla Srinivas; Mukhopadhyay Debasmita; Ganganna Bogonda; Vijeender Kandi; Srihari Pabbaraja; Reddy Chada Raji; Ramaiah M Janaki; Bhadra Utpal

来源：Bioorganic & Medicinal Chemistry Letters, 2012, 22(1): 645-648.

DOI：10.1016/j.bmcl.2011.10.061

• aza-Flavones
• MicroRNA inhibitors
• Drosophila
• Cell cycle arrest
• Apoptosis

aza-Flavanones have been identified as a new class of selective microRNA inhibitors. These compounds were found to arrest cell cycle via a novel cross species microRNA-dependent regulatory pathway interpreting an unexpected link between cell cycle arrest and microRNA mediated control in cancer.

• 出版日期2012-1-1