Addition of neuA, the gene encoding N-acylneuraminate cytidylyl transferase, increases the discriminatory ability of the consensus sequence-based scheme for typing Legionella pneumophila serogroup 1 strains

作者：Ratzow Sandra; Gaia Valeria; Helbig Juergen Herbert; Fry Norman K; Lueck Paul Christian

来源：Journal of Clinical Microbiology, 2007, 45(6): 1965-1968.

DOI：10.1128/JCM.00261-07

The standard sequence-based method for the typing of Legionella pneumophila serogroup I strains was extended by using the gspA and neuA alleles. The use of neuA as a seventh allele for typing significantly increased the index of discrimination calculated for a panel of unrelated strains (from 0.932 to 0.963) and subdivided some known large common complexes (e.g., 1,4,3,1,1,1). This modification to the standard method is proposed as the method of choice in the epidemiological investigation of L. pneumophila infections.

• 出版日期2007-6
• 单位河北医科大学