Attenuation of A beta toxicity by promotion of mitochondrial fusion in neuroblastoma cells by liquiritigenin

作者：Jo Doo Sin; Shin Dong Woon; Park So Jung; Bae Ji Eun; Kim Joon Bum; Park Na Yeon; Kim Jae Sung; Oh Jeong Su; Shin Jung Won^*; Cho Dong Hyung^*

来源：Archives of Pharmacal Research, 2016, 39(8): 1137-1143.

DOI：10.1007/s12272-016-0780-2

• Mitochondria dynamics
• Fusion/fission
• Liquiritigenin
• Amyloid beta

Mitochondrial dynamics control mitochondrial morphology and function, and aberrations in these are associated with various neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. To identify novel regulators of mitochondrial dynamics, we screened a phytochemical library and identified liquiritigenin as a potent inducer of mitochondrial fusion. Treatment with liquiritigenin induced an elongated mitochondrial morphology in SK-N-MC cells. In addition, liquiritigenin rescued mitochondrial fragmentation induced by knockout of mitochondrial fusion mediators such as Mfn1, Mfn2, and Opa1. Furthermore, we found that treatment with liquiritigenin notably inhibited mitochondrial fragmentation and cytotoxicity induced by A beta in SK-N-MC cells.

• 出版日期2016-8