Feasibility of shutter-speed DCE-MRI for improved prostate cancer detection

作者：Li Xin^*; Priest Ryan A; Woodward William J; Tagge Ian J; Siddiqui Faisal; Huang Wei; Rooney William D; Beer Tomasz M; Garzotto Mark G; Springer Charles S Jr

来源：Magnetic Resonance in Medicine, 2013, 69(1): 171-178.

DOI：10.1002/mrm.24211

• shutter-speed
• DCE-MRI
• prostate

The feasibility of shutter-speed model dynamic-contrast-enhanced MRI pharmacokinetic analyses for prostate cancer detection was investigated in a prebiopsy patient cohort. Differences of results from the fast-exchange-regime-allowed (FXR-a) shutter-speed model version and the fast-exchange-limit-constrained (FXL-c) standard model are demonstrated. Although the spatial information is more limited, postdynamic-contrast-enhanced MRI biopsy specimens were also examined. The MRI results were correlated with the biopsy pathology findings. Of all the model parameters, region-of-interest-averaged Ktrans difference [?Ktrans = Ktrans(FXR-a) - Ktrans(FXL-c)] or two-dimensional Ktrans(FXR-a) vs. kep(FXR-a) values were found to provide the most useful biomarkers for malignant/benign prostate tissue discrimination (at 100% sensitivity for a population of 13, the specificity is 88%) and disease burden determination. (The best specificity for the fast-exchange-limit-constrained analysis is 63%, with the two-dimensional plot.) Ktrans and kep are each measures of passive transcapillary contrast reagent transfer rate constants. Parameter value increases with shutter-speed model (relative to standard model) analysis are larger in malignant foci than in normal-appearing glandular tissue. Pathology analyses verify the shutter-speed model (FXR-a) promise for prostate cancer detection. Parametric mapping may further improve pharmacokinetic biomarker performance. Magn Reson Med, 2013.

• 出版日期2013-1