Novel bioactive vic-dioxime ligand containing piperazine moiety: Synthesis, X-ray crystallographic studies, 2D NMR applications and complexation with Ni(II)

作者：Yilmaz Aytek; Taner Bilge; Deveci Pervin; Obali Aslihan Yilmaz; Arslan Ugur; Sahin Ertan; Ucan H Ismet; Ozcan Emine^*

来源：Polyhedron, 2010, 29(15): 2991-2998.

DOI：10.1016/j.poly.2010.08.006

• vic-Dioxime
• Nickel(II) complexes
• Piperazine moiety
• ID and 2D NMR
• Crystal structure
• Antimicrobial activity

A new vic-dioxime ligand bearing an important pharmacophore substituent, anti-1-(4-benzylpiperazine-1-yl) phenylglyoxime (LH(2)) (Scheme 1), has been synthesized and its nickel(II) complex was obtained by the reaction of NiCl(2)center dot 6H(2)O and the ligand. The characterization of the newly formed compounds was performed by elemental analysis, FT-IR, 1D NMR ((1)H, (13)C, DEPT), 2D NMR (HMBC), ESI mass-spectrometry, TG/DTA, X-ray crystallography. The antibacterial activity was also studied against Staphylococcus aureus ATCC 25923, Streptococcus mutans RSHM 676, Enterococcus faecalis ATCC 29212, Lactobacillus acidophilus RSHM 06029, Escherichia coli ATCC 25922, E. coli ATCC 35218, Pseudomonas aeruginosa ATCC 27853. The antimicrobial test results indicated that all the compounds have mild antibacterial activity against both Gram negative and Gram positive bacterial species.

• 出版日期2010-10-14