科研之友
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摘要
What is known and objective In China, lidocaine together with 2mg/mL of pingyangmycin (PYM, also known as bleomycin A5) is recommended for the treatment of venous malformations (VMs). The purpose of this study was to investigate whether lidocaine has a synergistic effect with PYM in improving the therapeutic outcomes of patients with VMs. Additionally, this study aimed to evaluate the outcomes of sclerotherapy for VMs using an intralesional injection of a low concentration of PYM (0 center dot 5mg/mL). Methods A total of 281 patients with VMs were treated with 0 center dot 5 or 2mg/mL of PYM with or without lidocaine and dexamethasone (DEX). All of the patients received a direct intralesional injection at a rate of 1mL/min, and the volume of the solution varied from 1 center dot 5 to 6 center dot 0mL per injection. Results and discussion No significant differences were observed in the clinical outcomes between the PYM and PYM+lidocaine treatment groups (0 center dot 05). The clinical outcomes were similar between the groups that were treated with 0 center dot 5 and 2mg/mL of PYM, but the swelling and pain in the patients who were treated with 0 center dot 5mg/mL of PYM were less severe compared with the patients who were treated with 2mg/mL of PYM. A total of 29 patients with VM lesions on the glans penis were treated with 0 center dot 5mg/mL of PYM+0 center dot 5% lidocaine. Of these patients, 26 were cured, whereas three experienced a marked improvement. What is new and conclusion Lidocaine does not have a synergistic effect with PYM in improving the therapeutic outcomes of patients with VMs. Sclerotherapy with a low concentration of PYM (0 center dot 5mg/mL) combined with lidocaine and DEX is a safe and effective therapy for small superficial VMs of critical organs, such as the lips and the glans penis.
- 出版日期2014-10
- 单位临沂市人民医院; 青岛大学
