摘要
Twelve new dihydroagarofuran sesquiterpene polyol esters, triptersinines A-L (1-12), and eight known sesquiterpene pyridine alkaloids were isolated from the leaves of Tripterygium wilfordii. Their structures were elucidated on the basis of spectroscopic analyses, including UV, IR, and NMR experiments (H-1-H-1 COSY, NOESY, HSQC, and HMBC). Furthermore, in an in vitro bioassay, compounds 1, 9, 11, 13, 14, and 18 showed moderate inhibitory effects on nitric oxide production in LPS-induced macrophages at 5 mu M; all compounds were inactive when tested against five human cancer cell lines (IC50 values > 1 mu M).
- 出版日期2013-1
- 单位北京协和医学院; 中国医学科学院北京协和医院; 天然药物活性物质与功能国家重点实验室