CATALYTIC AND ENANTIOSELECTIVE SYNTHESIS OF A KEY INTERMEDIATE OF THE MCHr1 ANTAGONIST AMG 076

作者：Harada Shinji^*; Ishii Haruka; Shirasaki Daisuke; Nishida Atsushi

来源：Heterocycles, 2015, 90(2): 967-977.

DOI：10.3987/COM-14-S(K)64

• Decahydroisoquinoline
• Diels-Alder Reaction
• Chiral Ytterbium Complex
• AMG 076

A chiral decahydroisoquinoline was constructed using our asymmetric Diels-Alder reaction catalyzed by a chiral Yb (ytterbium) complex as a key step. The decahydroisoquinoline is a synthetic intermediate of the anti-obesity drug candidate AMG 076 (Amgen).

• 出版日期2015-1-1