Diagnostic and prognostic correlates of preoperative FDG PET for breast cancer

作者：Vinh Hung Vincent^*; Everaert Hendrik; Lamote Jan; Voordeckers Mia; van Parijs Hilde; Vanhoeij Marian; Verfaillie Guy; Fontaine Christel; Vees Hansjoerg; Ratib Osman; Vlastos Georges; De Ridder Mark

来源：European Journal of Nuclear Medicine and Molecular Imaging, 2012, 39(10): 1618-1627.

DOI：10.1007/s00259-012-2181-1

• Breast cancer
• Prognosis
• Survival
• Lymph nodes
• Staging
• Surgery

To explore the preoperative utility of FDG PET for the diagnosis and prognosis in a retrospective breast cancer case series. %26lt;br%26gt;In this retrospective study, 104 patients who had undergone a preoperative FDG PET scan for primary breast cancer at the UZ Brussel during the period 2002-2008 were identified. Selection criteria were: histological confirmation, FDG PET performed prior to therapy, and breast surgery integrated into the primary therapy plan. Patterns of increased metabolism were recorded according to the involved locations: breast, ipsilateral axillary region, internal mammary chain, or distant organs. The end-point for the survival analysis using Cox proportional hazards was disease-free survival. The contribution of prognostic factors was evaluated using the Akaike information criterion and the Nagelkerke index. %26lt;br%26gt;PET positivity was associated with age, gender, tumour location, tumour size %26gt; 2 cm, lymphovascular invasion, oestrogen and progesterone receptor status. Among 63 patients with a negative axillary PET status, 56 (88.9 %) had three or fewer involved nodes, whereas among 41 patients with a positive axillary PET status, 25 (61.0 %) had more than three positive nodes (P %26lt; 0.0001). In the survival analysis of preoperative characteristics, PET axillary node positivity was the foremost statistically significant factor associated with decreased disease-free survival (hazard ratio 2.81, 95% CI 1.17-6.74). %26lt;br%26gt;Preoperative PET axillary node positivity identified patients with a higher burden of nodal involvement, which might be important for treatment decisions in breast cancer patients.

• 出版日期2012-10