Lack of replication for the myosin-18B association with mathematical ability in independent cohorts

作者：Pettigrew K A; Valles S F Fajutrao; Moll K; Northstone K; Ring S; Pennell C; Wang C; Leavett R; Hayiou Thomas M E; Thompson P; Simpson N H; Fisher S E; Whitehouse A J O; Snowling M J; Newbury D F; Paracchini S^*

来源：Genes, Brain and Behavior, 2015, 14(4): 369-376.

DOI：10.1111/gbb.12213

• ALSPAC
• cognitive abilities
• dyscalculia
• dyslexia
• genetic association
• neurodevelopmental disorders

Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N=3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities.

• 出版日期2015-4