Antitumoral effects of vasoactive intestinal peptide in human renal cell carcinoma xenografts in athymic nude mice

作者：Vacas Eva; Isabel Arenas M; Munoz Moreno Laura; Bajo Ana M; Sanchez Chapado Manuel; Prieto Juan C^*; Carmena Maria J

来源：Cancer Letters, 2013, 336(1): 196-203.

DOI：10.1016/j.canlet.2013.04.033

• VIP
• MMP
• VEGF
• NF kappa B
• ccRCC

We studied antitumor effect of VIP in human renal cell carcinoma (RCC) (A498 cells xenografted in immunosuppressed mice). VIP-treated cells gave resulted in p53 upregulation and decreased nuclear beta-catenin translocation and NP kappa B expression, MMP-2 and MMP-9 activities, VEGF levels and CD-34 expression. VIP led to a more differentiated tubular organization in tumours and less metastatic areas. Thus, VIP inhibits growth of A498-cell tumours acting on the major issues involved in RCC progression such as cell proliferation, microenvironment remodelling, tumour invasion, angiogenesis and metastatic ability. These antitumoral effects of VIP offer new therapeutical possibilities in RCC treatment.

• 出版日期2013-8-9