A SURVEY OF ANTIBODIES FOR THE EXTRACTABLE NUCLEAR ANTIGENS AND THEIR ROLE IN THE CLINICAL DIAGNOSIS AND PROGNOSIS OF SLE

作者：Shahnaz Rafiei Tehrani; & Tahereh Mousavi; & Mahmoud Akbarian

来源：Acta Medica Iranica, 1993.

Fifty-seven patients suffering from systemic lupus erythematosus with different clinical features were studied from various aspects of immunological abnormalities, including anti-nuclear antibodies; anti-DNA; anti-Sm (Smith%26apos;s antigen); and, other extractable nuclear antigens.%26quot;nThe tests employed were microhemagglutination, counter immunoelecterphoresis, and radio immunoassay (RIA).%26quot;nThe comparison between the two techniques for detectiong anti-DNA titers showed a significant correlation between them. There was also a significant positive correlation between the presence of anti-DNA and lupus nephritis (P%26gt;O.05). However, lupus nephritis has a negative association with anti-Sm.%26quot;nWe will discuss anti-Sm in SLE patients that may have an inhibitory effect on developing the lupus nephritis. The association of anti-Sm in SLE may help the physicians to prognose the disease and manipulate the treatment.

• 出版日期1993