ApoB-100, ApoE and CYP7A1 gene polymorphisms in Mexican patients with cholesterol gallstone disease

作者：Jaime Sanchez Cuen; Maribel Aguilar Medina; Eliakym Arambula Meraz; Jose Romero Navarro; Julio Granados; Laura Sicairos Medina; Rosalio Ramos Payan^*

来源：World Journal of Gastroenterology, 2010, 16(37): 4685-4690.

DOI：10.3748/wjg.v16.i37.4685

• Apolipoprotein
• CYP7A1
• Gallstones
• Mexicans
• Polymorphisms

AIM: To determine the possible association of the ApoB-100 (Xba I), ApoE (Hha I) and CYP7A1 (85a I) gene polymorphisms, with the development of cholesterol gallstone disease (GD) in a Mexican population.
METHODS: The polymorphisms were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism, in two groups matched by ethnicity, age and sex: patients with GD (n = 101) and stone-free control subjects (n = 101).
RESULTS: Allelic frequencies in patients and controls were: 34.16% vs 41.58% (P = 0.124) for X+If of ApoB-100; 4.46% vs 5.94% (P = 0.501) for E2, 85.64% vs 78.22% (P = 0.052) for E3, 9.90% vs 15.84% (P = 0.075) for E4 of ApoE; and 25.74% vs 27.72% (P = 0.653) for C of CYP7A1. Differences in genotypic frequencies between the studied groups were not significant (P < 0.05).
CONCLUSION: These results demonstrated that no association exists between the studied polymorphisms and cholelithiasis in this high prevalent population.

• 出版日期2010-10-7